Two doctors reviewing brain scans

NeuroCritical Care Research

Research at the University of Chicago Neurointensive care unit builds up on a strong and deep legacy for nearly a century. 

Clinical Trials

Looking at brain scan on an ipad

Brain Oxygen Optimization in Severe TBI Phase-3 (BOOST3)

BOOST3 is a randomized clinical trial to compare two strategies for monitoring/treating Traumatic brain injury (TBI) patients in the ICU. One strategy is based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) while the other is guided by treatment goals based on ICP monitoring alone. The results of this study will help doctors discover which method is optimal.

rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST)

FASTEST trial is a phase III, randomized, double-blind controlled trial of rFVIIa plus best standard therapy vs. placebo and best standard therapy alone in patients with intracranial hemorrhage. The FASTEST Trial will include approximately 100 hospital sites across the world and key global institutions with large volumes of ICH patients and the ability to treat them within 120 minutes of stroke onset. 

Translational Research: Novel Diagnostic and Prognostic Markers

Gut Microbiome in Acute Brain Inury

Growing evidence suggests a role for gut microbiota in modulating central nervous system function, in the modulation of cellular mechanisms that follow an acute brain injury. Our Group, in collaboration with Dr. xx are studying this phenomenon in the acutely ill neurocritical care patients.